What is a pathology system?

July 26, 2022

The study of disease through the integration of clinical, morphological, quantitative, and molecular parameters using mathematical analytical frameworks is known as systems pathology.

Definition:

The study of disease through the integration of clinical, morphological, quantitative, and molecular parameters using mathematical analytical frameworks is known as systems pathology. The goal is to develop coherent models that allow for a comprehensive understanding of pathophysiological processes and to generate hypotheses that can be tested experimentally. In practice, systems pathology aims to provide patients with personalized therapy and predictive outcomes.

Pathology's digital transformation has enabled the digitization of glass slides in order to generate whole slide images (i.e., WSIs or digital slides). A digital pathology system's primary components include a whole slide scanner, software whole slide image viewer, and display monitor. Pathologists can use digital pathology to access, evaluate, and share pathology slides using a digital workflow, and it also allows for easy remote sign-out when necessary. It provides pathologists with a novel way to review and render diagnoses, broadens clinical expertise, and allows for digital management of pathology slides for patient specimen reporting. A plethora of literature has been published to demonstrate the concordance of rendering diagnoses using WSIs versus glass slides. These studies have demonstrated that using WSIs, pathology specimen reporting is simple and can be incorporated into routine anatomic pathology laboratory workflow. Furthermore, pathologists can use digital pathology to create and improve a digital workflow. Patients benefit from experienced sub-specialized expert pathologists at cancer centers such as Memorial Sloan Kettering Cancer Center (MSK). Digital pathology has also improved the pathologist's experience while providing efficiency and cost savings.

Pathologists are required by Clinical Laboratory Improvement Amendments (CLIA) regulations to electronically verify patient reports from CLIA-certified facilities [26]. During the COVID-19 pandemic, however, this requirement could have exposed pathologists and trainees to the SARS-CoV-2 virus, putting the pathologist, colleagues, and household members at risk of infection from a potentially lethal virus. Furthermore, in the event of a public health emergency, if pathologists are unable to be present at the CLIA-licensed facility due to illness, quarantine, or other travel restrictions, hospital systems will lose continuous patient care and pathology reporting turnaround times. Many pathologists have secure access (e.g., virtual private networks) to hospital information systems (e.g., laboratory information systems, electronic health record) and can connect to them from remote locations (e.g., home). With the advent of digital pathology, novel digital workflows can be implemented and validated for remote use at this time.

Characteristics:

Pathology is the study of disease mechanisms and diagnosis, and it is the foundation of all Laboratory Medicine elements such as hematology, immunology, biochemistry, microbiology, genetics, and anatomic/histopathology. Pathology is derived from the Ancient Greek pathos, which means "feeling, suffering," and -o, -logia, which means "study of." Pathology focuses on four major aspects of disease.

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Reference Digital Pathology UCGconferences press releases and blogs

https://medium.com/@taania.ucg/what-is-digital-pathology-932897b40e03

https://kikoxp.com/posts/13185

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https://sites.google.com/view/digitalpathologyucg/what-is-digital-pathology

https://digitalpathologyucg.blogspot.com/2022/07/what-is-digital-pathology.html

https://digitalpathologyucg915618148.wordpress.com/2022/07/04/what-is-digital-pathology/

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